Using combos can be very easy. You can make Energy Strike combos or Sudden Death combos with a team. To make Energy Strike combos just put the hotkey and press it combining it with a Wand/Rod. The same happens with Sudden Death, just that you need a team.
Remember though, you should cast the rune immediately after you do damage with your wand since you will attack again 2 seconds after the cast due to exhaustion.
Another type of combo is using a bow or crossbow in combination with a rune or spell on a hotkey.