Paralyzes target. Any healing spell on the paralyzed target will cancel the effect.
This is a very expensive rune, which can only be used/created by druids. Not only does it cost 1400 mana to make, but it also requires 1400 mana and 3 soul points to use. The only other rune that requires mana to use is the Convince Creature rune.
Many creatures are immune to Paralysis, and any creatures that are Self-Healing will cancel the paralysis when they heal themselves.
Paralyze runes are mostly used in war. Since you can heal only once per step, the paralyze rune will slow down your opponent and allow your team to combo the enemy to death.
This rune was once available for all vocations with magic level 18 and higher to use, however a patch changed this. It costs 6000 Soul Points per Backpack.